Dual Regulation of Akt/Protein Kinase B by Heterotrimeric G Protein Subunits
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چکیده
منابع مشابه
Conditional regulation of adenylyl cyclases by G-protein by-subunits
14. Hrandt, H. I,., Hagiwara, S., Kidokoro, Y. and Miyazaki, S. (1976) J. Physiol. (London) 263, 4 17-439 Grohovaz, F., Zacchetti, I)., Clementi, E., Lorenzon, P., Meldolesi, J. and Fumagalli, G. (1991) J. Cell Hiol. 133, 1831-1350 Kidokoro, Y. and Kitchie, A. K. (1980) J. Physiol. (London) 307, 199-216 Fenwick, E. M., Marty, A. and Neher, E. (1982) J. Physiol. (London) 331, 599-635 Hallesta, J...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m007403200